Furthermore, how effacement of podocytes is related to proteinuria and vice versa is a matter of debate. It can also refer to a process occurring in podocytes in nephrotic syndrome. Injury to podocytes results in loss of foot processes commonly referred to as “effacement.” Effacement is believed to be initiated by changes in the podocyte actin cytoskeleton that also determine the shape and architecture of podocytes (27, 41). Additional terms or revisions may be requested through our issue tracker at GitHub. podocyte effacement), vacuolation, and growth of microvilli on the visceral epithelial cells, allowing for excess protein loss in the urine. This review summarizes the various structural responses of podocytes to injury, focusing on foot process effacement and detachment. 34 The foot processes broaden and efface.

RESEARCH DESIGN AND METHODS Apoptosis, albuminuria, ROS generation, NADPH superoxide generation, CYP4A and Nox protein … Foot process effacement is the most prominent and, yet in some ways, the most enigmatic of those changes. It is considered to be a stereotypical reaction of podocytes to injury or damage.

By light microscopy, the glomerulus is normal with MCD. SIGNIFICANCE OF FOOT PROCESS EFFACEMENT IN GLOMERULAR FUNCTION Podocytes are involved in a variety of glomerular functions, including maintenance of the ï¬ ltration barrier, regulation of glomerular ï¬ ltration, support of the capillary tuft, GBM-turnover, and immunological functions (Mundel and Kriz 1995). To evaluate the relationship between proteinuria and foot process effacement in human glomerulopathies, we conducted a morphologic study on podocyte foot processes in renal biopsies obtained from three groups of patients with proteinuric glomerulopathies and in normal human kidney. A Loss of the foot processes of the podocytes (i.e., podocyte effacement) is a hallmark of minimal change disease, which has therefore … Genetic mutations of proteins that are required for podocyte function or direct antibody mediated injury of podocytes may lead to podocyte effacement and dysfunction of the normal signaling between podocytes and endothelium. … Histological diagnosis: immune complex-mediated necrotizing and crescentic glomerulonephritis. Podocytes respond to stress and injury by undergoing tremendous changes in shape. Please contact us with any other questions about the Mammalian Phenotype Ontology.. Foot process effacement is the most prominent and, yet in some ways, the most enigmatic of those changes. Chronic podocyte injury may lead to podocyte detachment from the GBM. The exact mechanism resulting in … Figure 8 presents two examples of tuft areas (from rats after growth stimulation with FGF-2) , in which several neighboring podocytes are undergoing detachment. OBJECTIVE We investigated the role of cytochrome P450 of the 4A family (CYP4A), its metabolites, and NADPH oxidases both in reactive oxygen species (ROS) production and apoptosis of podocytes exposed to high glucose and in OVE26 mice, a model of type 1 diabetes.