These genes have consensus sequences for GLI1 binding in their 5'upstream promoter region. Title: Hedgehog Target Genes: Mechanisms of Carcinogenesis Induced by Aberrant Hedgehog Signaling Activation VOLUME: 9 ISSUE: 7 Author(s):Y. Katoh and M. Katoh Affiliation:Genetics and Cell Biology Section, National Cancer Center, 5-1-1 Tsukiji, Chuo Ward, Tokyo 104-0045, Japan. Published by Guset User , 2015-06-01 03:22:02 Description: which hedgehog target gene dysregulation produces at … Reports have shown that Cyclin D2 is up-regulated while Plakoglobin is down-regulated by GLI1 in epithelial transformed cell lines [ 13 ]. To comprehensively characterize Hh-signaling driving mRNA changes in our system, we performed RNA-Seq analysis on the mRNA isolated from NIH3T3-pc3.1 cells treated with vehicle control or 1 % Hh ligand conditioned medium (Hh-CM). Hedgehog Target Genes: Mechanisms of Carcinogenesis Induced by Aberrant Hedgehog Signaling Activation Buy Article: $68.00 + tax (Refund Policy) Authors: Katoh, Y.; Katoh, M. Source: Current Molecular Medicine, Volume 9, Number 7, 2009, pp. Downstream target genes of GLI1 are PTCH1, Wnt, as well as other genes such as Cyclin D2 and Plakoglobin. Keywords:Hedgehog, WNT, Notch, FGF, TGF-ß, self-renewal, invasion, peritoneal dissemination Mutations in hedgehog signaling pathway genes, especially PTC1 and SMO, are pivotal to the development of basal cell carcinomas. The study of basal cell carcinoma gene expression not only may elucidate mechanisms by which hedgehog signaling abnormalities produce aberrant tumor cell behavior but also can provide data on in vivo hedgehog target gene control in humans. Hedgehog signaling and Esrrb regulated genes.