ANA incidence can be considered in two categories: A) A few drugs induce ANA in most patients if therapy is continued for long enough at high enough dosage. A positive ANA test is usually reported as both a ratio (called a titer) and a pattern, such as smooth or speckled. Also the biologic medications like Remicade, Humira, Enbrel can cause false positive results. It is important to talk with your doctor about all the drugs you are taking - prescription, over-the-counter, and street. Other conditions, such as cancer, can cause a … Positive ANA Getting Started. Welcome to the Positive ANA Decision Guide. Estrogens, oral contraceptives Danazol Mesalazine Reserpine Griseofulvin Clonidine Hydroxyurea Gemfibrozil Allopurinol Quinine Minoxidil Calcium channel blockers Amiodarone Spironolactone Clozapine Tocainide Zafirlukast Omeprazole Some medications cause a positive ANA or they highly suspected to lead to lupus condition they include birth control pills or Estrogens, Danazol, Mesalazine, Reserpine, Griseofulvin, Clonidine, Hydroxyurea Gemfibrozil, Allopurinol, Quinine, Minoxidil, Calcium channel blockers, Amiodarone, Spironolactone, Clozapine, Tocainide, Zafirlukast, Omeprazole among others. Many of these patients develop systemic lupus erythematosus like-syndromes. Some medications can cause a positive ANA. B) A further Oh man, Okie. A positive ANA test means that you have high levels of ANA in your blood. Certain medications, such as hydralazine, isoniazid, procainamide, and some anticonvulsant medications increase the chances of having a positive ANA test ". This group includes procainamide, hydrallazine at high doses and practolol. Even healthy people with viral infections can have a positive ANA, albeit for a short time. This decision guide is designed for persons with a positive antinuclear antibody (ANA) who would like to find out more about this test and what the test result may mean.